Description: Next generation sequencing (NGS) technologies allow us to sequence DNA and RNA quickly and cheaply than that was previously possible, revolutionizing the study of genomics and molecular biology, ultimately guiding clinical decision making in Precision Medicine. The mini-course will comprise of 6 instructed sessions and one hands-on tutorial session, and a mini-essay will be due in the last session. In an instructional session, first I will give an overview of the topic, guided by a classic review paper. Then, one (or two depending on the class strength) student(s) will present a research paper engaging the class in a scholarly group discussion. The students will learn about the emerging applications of the next generation sequencing technologies, best practice guidelines, key considerations during design of experiments, and interpretation of results.
Grading: Grading will be based on (i) participation in the discussion during the instructed sessions, and (ii) a mini proposal (~1000 words) due in the last class. The proposal will describe a possible NGS-based investigation the student might conduct in their area of research interest outlining Significance, Approach, and Expected Results and potential pitfalls in ~1000 words. Grading will be relative, and will be based on intuitive thinking in classroom setting (rather than domain knowledge).