Description: All toll-like receptor (TLR) family members are activated by signals produced by invading microorganisms. However, several TLRs also activated by signals derived from damaged host tissues and/or bacteria that live in the gut. In this course we will examine mechanisms by which TLRs regulate inflammatory responses, and link these processes to host homeostasis as well as human diseases. After successfully completing this course students will have a working knowledge of topics that extend from TLRs to cell signaling, host immunity, and immune cells interaction with the gut microbiome. The classes require active participation and will emphasize students-led critical evaluation and discussion of assigned current literature.
Instructor: Beatrice Haimovich