My interest is in how an inflammatory environment and insults to the lungs, including respiratory viruses, impact contractility and relaxation of the airways to help us determine pathways that can be manipulated to develop novel therapeutics (or improve current therapeutics) to treat obstructive respiratory diseases like asthma. My laboratory examines these pathways through the use of a number of models, with particular emphasis on the use primary human airway epithelial cells and airway smooth muscle, but also through the use of human precision cut lung slices. We study the physiology and pharmacology of airway constriction and dilation, particularly following Rhinovirus (common cold virus) exposure. We have a primary focus on G protein receptor and receptor tyrosine kinase signal transduction leading to augmentation of contractile, or attenuation of relaxant, responses in the lung.
Program Faculty
- Cynthia Koziol-White
- Assistant Professor
- Department: Department of Pharmacology
- Graduate Program(s): Cellular and Molecular Pharmacology
- Major Research Interest(s): Cytoskeleton, Drug Discovery, Pathogenesis, Signaling
- Research Techniques: Cell Biology, Cell culture, Fluorescent and super resolution microscopy, Imaging
- Research Organism(s): Humans, in vitro, Mice, Viruses
- Phone: 1.7322357170
- Email:
This email address is being protected from spambots. You need JavaScript enabled to view it. - Robert Wood Johnson Medical School
- Child Health Institute of New Jersey CHI, Room 4268
- 89 French Street
- New Brunswick, NJ 08901-1935
- Key Words: Respiratory pharmacology, heterogeneity of response in respiratory disease
- Lab Site URL