Program Faculty

Our lab investigates how genes are turned on and off in living cells, with a particular focus on a fascinating protein called NDF (Nucleosome Destabilization Factor). Think of DNA as a tightly wound thread around spools (called nucleosomes) – this packaging helps organize our genetic material but can make it difficult for cells to read genes when needed. Our research has revealed that NDF acts like a molecular machine that helps loosen this packaging, making it easier for cells to access and read important genetic information. We recently discovered that NDF is an ancient protein found in organisms ranging from simple yeast to humans, suggesting it plays a fundamental role in how cells work. Using cutting-edge techniques like cryo-electron microscopy and single-molecule analysis, we're uncovering exactly how NDF helps cells read their genes. This work has exciting implications for understanding both normal cell development and diseases like cancer, where NDF levels are often abnormal. We're looking for motivated students interested in combining biochemistry, genetics, and advanced imaging techniques to understand the basic mechanisms of gene regulation. Our lab offers training in state-of-the-art approaches including CRISPR genome editing, protein structure determination, and genomic analysis. If you're excited about discovering how cells control their genes and want to work at the intersection of biochemistry and genetics, we'd love to hear from you!

Publications