My research focuses on the molecular mechanisms involved in Parkinson's Disease (PD) and Dementia with Lewy Bodies (DLB), with a focus on the role of alpha-synuclein and noncoding RNAs. In both PD and DLB, the abnormal accumulation of alpha-synuclein in neurons leads to neurodegeneration. My work specifically investigates how noncoding RNAs, including microRNAs, regulate alpha-synuclein expression and aggregation. By modulating pathways, these noncoding RNAs influence the clearance of alpha-synuclein and its toxic aggregates. My research aims to identify therapeutic strategies that target these noncoding RNAs to mitigate alpha-synuclein-related pathology and provide potential treatments for PD and DLB.
Program Faculty
- Eunsung Junn
- Associate Professor
- Department: Department of Neurology
- Graduate Program(s): Cell and Developmental Biology | Microbiology and Molecular Genetics
- Major Research Interest(s): Aging, Apoptosis / autophagy, Cell stress / Cell death, Neurological disease, RNA / ribosome biology
- Research Techniques: Biochemistry, Cell Biology, Cell culture, Transcriptomics
- Research Organism(s): Bacteria, Cell lines, Humans, in silico, in vitro, Mice, Viruses, Yeast
- Phone: 1.7322355478
- Email:
This email address is being protected from spambots. You need JavaScript enabled to view it. - Robert Wood Johnson Medical School
- RWJMS Research Building & School of Public Health, Room 185
- 683 Hoes Lane West
- Piscataway, NJ 08854
- Key Words: Parkinson's Disease, Dementia with Lewy Bodies, alpha-Synuclein, microRNA