The major focus in the laboratory is to determine how obesity and loss of body weight alleviate risk of disease and contribute to the risk of osteoporosis. A focus in the lab is to determine mechanisms that regulate inflammation, cognition and bone metabolism and the role of specific nutrients such as vitamin D, protein and calcium. We recently have been addressing how circadian rhythm affects health (including bone, microbiome, cognition, circadian markers and sleep). Hormones, bone turnover and gut peptides are measured using techniques of spectrophotometry, and HPLC, and stable isotopes and mass spec to assess absorption. The lab examines healthy older individuals with a focus on obesity and imaging methods and has an interest in ethnic/ racial differences during weight loss and in those with metabolic syndrome. There is a clinical and translational research that emphasizes the endocrine regulation of obesity with focus area on circadian rhythm, inflammation, gastrointestinal absorption and the microbiome, and dietary interventions altering metabolism during weight reduction. Studies also examine how specific foods affect hormones and health outcomes.

Publications

NCBI Bibliography