Dr. Kim’s research focuses mainly on the elucidation of the molecular mechanisms underlying oxidative stress-related nigrostriatal degeneration in Parkinson’s disease (PD) using a range of rodent PD models. He reported for the first time that NADPH oxidase 1 (NOX1) is expressed in dopaminergic neurons and that NOX1-derived ROS is responsible for dopaminergic neuronal degeneration and α-synuclein aggregation, which are pathological hallmarks of PD. Currently, his research is expanding to investigate the molecular mechanisms governing oxidative stress-mediated α-synuclein changes including epigenetic and translational regulation as well as protein aggregation and impact on mitochondrial functions. He has recently introduced the innovative concept of transcriptional mutagenesis (TM) of the SNCA gene and its contribution to PD pathogenesis. This original idea is widely applicable to other neurodegenerative conditions including Dementia with Lewy Bodies (DLB) and Alzheimer’s disease. His research pipeline is highly interdisciplinary and integrates core areas of neurodegenerative diseases.
Program Faculty
- Yoon-Seong Kim
- Professor
- Department: Department of Neurology
- Graduate Program(s): Cell and Developmental Biology
- Major Research Interest(s): Aging, Epigenetics/ Chromatin, Gene regulation, Microbiome, Neurological disease
- Research Techniques: Cell culture, Fluorescent and super resolution microscopy, Genomics, Single Cell RNA Techniques, Transcriptomics
- Research Organism(s): Cell lines, Humans, Mice
- Phone: 1.732236499
- Email:
This email address is being protected from spambots. You need JavaScript enabled to view it. - Robert Wood Johnson Medical School
- RWJMS Research Building & School of Public Health
- 683 Hoes Lane West
- Piscataway, NJ 08854-8021
- Key Words: Oxidative stress-mediated neuronal death mechanism underlying Parkinson’s disease and Alzheimer disease
- Lab Site URL