Description: Epigenetic mechanisms, including DNA methylation, histone post translational modifications, and regulation of chromatin structure, play central roles in cancer initiation, progression, metastasis, and therapy resistance. Tumors frequently co-opt “writers”, “readers”, “erasers”, and chromatin remodelers to reprogram gene expression. Pharmacologic modulation of these regulators has yielded approved agents and an expanding clinical pipeline. This minicourse surveys key epigenetic regulators in tumorigenesis and review approved and investigational epigenetic therapies to illuminate opportunities and limitations in cancer treatment.
Structure: The first session will be an introductory lecture on cancer epigenetics delivered by the instructor. In the subsequent six sessions (Sessions 2-7), the format will be as follows: (1) a student will deliver a 45-minute paper presentation on a selected research article about the previous session’s topic; (2) the instructor will present a 30-minute lecture on a specific topic related to cancer epigenetics; and (3) a 15-minute question-and-answer session. In the final session, the format will be: (1) a student will deliver a 45-minute paper presentation on a selected research article about the previous session’s topic; and (2) a 45-minute Q&A and discussion session. Each student will be asked to answer at least one question in the final section.
Outcome: Students will build a working knowledge of cancer epigenetics, gain experience interpreting primary literature, and strengthen presentation and scientific discussion skills.
Grading: Attendance and participation, journal club presentation, engagement in discussions, and performance in the final Q&A session.
Course Materials: Students are expected to read the seven research articles presented in Sessions 2 to 8.