Description: Epigenetic mechanisms play a crucial role in cancer development, encompassing DNA methylation, histone post-translational modifications, and regulation of chromatin structure. Recent research indicates that tumors often exploit these epigenetic mechanisms to facilitate tumor initiation, progression, metastasis, and resistance to treatment. Consequently, the pharmaceutical modulation of epigenetic regulators, such as 'writers', 'readers', 'erasers', and 'remodelers', holds great promise in restoring a normalized epigenetic landscape and treating tumors. In this minicourse, we will delve into a comprehensive exploration of critical epigenetic regulators that contribute to tumorigenesis. Moreover, we will examine approved epigenetic medicines, as well as those currently under clinical trials, aiming to provide a comprehensive understanding of their potential in cancer treatment. Through this course, we hope to shed light on the latest developments in the field of cancer epigenetics and its potential implications in cancer therapy.
Structure: The first session will be an introductory lecture on cancer epigenetics, delivered by the instructor. In the subsequent six sessions (2nd to 7th), the format will be as follows: (1) the instructor will present a 30-minute lecture on a specific topic related to cancer epigenetics; (2) a student will conduct a 45-minute paper presentation on a selected research article; and (3) a 15-minute question and answer session. Students are required to submit questions to the instructor. A list of questions will be distributed to all students in the lead-up to the final week. Each student will select one question from the list. In the final session, students will conduct a brief 5-minute presentation followed by a 5-minute Q&A session dedicated to addressing their chosen question. These questions will be well-defined, requiring students to perform some literature searches without delving too deeply into the readings. Examples of questions and corresponding presentations will be provided during the first lecture.
Outcome: This minicourse aims to foster a comprehensive understanding of cancer epigenetics by combining instructor-led lectures, student-led paper presentations, and engaging Q&A sessions. It also provides an opportunity for students to deepen their knowledge and presentation skills through their individual research and presentations on specific topics.
Grading: Grading will be based on attendance, student presentation (journal club), question submission, student presentation (question addressing in the last class), and active engagement in discussions.